Chapter 1 of 432% of exam

Assess: History, Examination, Screening and Diagnostic Tests

Assess is the largest practice domain on the FNP blueprint. It covers gathering the subjective history, performing a focused or complete examination, and ordering, performing, and interpreting screening and diagnostic tests for patients from newborns to older adults. Most errors in this domain come from applying a screening rule to the wrong age or risk group, or from ordering a test that cannot answer the clinical question.

What the domain covers

The NPCB blueprint lists three tasks under Assess: obtaining subjective information such as the chief complaint, history, and review of systems; performing an appropriate focused or complete physical examination; and ordering, performing, and interpreting screening and diagnostic tests. Questions are spread across the lifespan, and the published age split weights older, middle, and young adults most heavily. The adolescent, young adult, and middle adult groups include prenatal care.

Three Assess tasks
History (chief complaint, history, review of systems), physical examination (focused or complete), and screening and diagnostic testing are the three tasks tested in this domain.
NPCB FNP Candidate Handbook (updated 06/2026), Appendix A
Lifespan age weighting
Of 135 scored items, older adults account for 30%, middle adults 26%, young adults 22%, adolescents 9%, and newborn through child 13% combined.
NPCB FNP Candidate Handbook (updated 06/2026), Appendix A, Domain II
Specialized assessments
The knowledge areas include developmental, functional, and psychological assessments alongside the health history and physical examination.
NPCB FNP Candidate Handbook, FNP Applied Knowledge Areas

Adult preventive screening

Screening questions test whether a recommendation applies to the patient in front of you: age, sex, risk factors, and pregnancy status all change the answer. USPSTF grades A and B mark services to offer, while a grade D means recommend against and an I statement means the evidence is insufficient. Several start ages were lowered in recent updates, so the edition matters.

Colorectal cancer
Screen all adults aged 50 to 75 (grade A) and adults aged 45 to 49 (grade B); offer screening selectively at 76 to 85.
USPSTF Colorectal Cancer: Screening, 2021
Breast cancer
Biennial screening mammography for women aged 40 to 74 (grade B); evidence is insufficient at 75 and older.
USPSTF Breast Cancer: Screening, 2024
Lung cancer
Annual low-dose CT for adults 50 to 80 with a 20 pack-year history who smoke now or quit within 15 years.
USPSTF Lung Cancer: Screening, 2021
Diabetes and hepatitis C
Screen adults 35 to 70 with overweight or obesity for prediabetes and type 2 diabetes, and screen all adults 18 to 79 once for hepatitis C.
USPSTF Prediabetes and Type 2 Diabetes: Screening, 2021; Hepatitis C: Screening, 2020
Osteoporosis and AAA
Screen women 65 and older (and younger postmenopausal women at increased risk) with DXA; offer one-time aortic ultrasound to men 65 to 75 who have ever smoked.
USPSTF Osteoporosis: Screening, 2025; Abdominal Aortic Aneurysm: Screening, 2019

Pregnancy, sexual health and adolescents

Prenatal screening follows a timeline: some tests belong at the first visit and some later in gestation. Sexual health screening depends on age and risk, and cervical cancer screening has both a start age and a stop age. With adolescents, the way the history is taken matters as much as the questions asked.

First prenatal visit
Rh(D) typing and antibody testing, syphilis screening, and a urine culture for asymptomatic bacteriuria (first visit or 12 to 16 weeks) are recommended early in pregnancy.
USPSTF Rh(D) Incompatibility; Syphilis in Pregnancy, 2025; Asymptomatic Bacteriuria, 2019
Gestational diabetes
Screen asymptomatic pregnant persons at 24 weeks or later; evidence is insufficient before 24 weeks.
USPSTF Gestational Diabetes: Screening, 2021
Cervical and STI screening
No cervical screening before 21 or after 65 with adequate prior screening; screen sexually active women 24 and younger for chlamydia and gonorrhea.
USPSTF Cervical Cancer: Screening, 2018; Chlamydia and Gonorrhea: Screening, 2021
Adolescent interview
Explain confidentiality and its legal limits and give the adolescent time alone; CRAFFT is a brief substance-use screen in which two or more yes answers suggest a serious problem.
AMA Journal of Ethics (Virtual Mentor), March 2005

Pediatric examination and point-of-care testing

Pediatric assessment questions test developmental milestones, age-specific examination findings, and when a test should or should not be done. Several guidelines exist mainly to prevent unnecessary testing and antibiotics, so knowing when not to test is part of the domain.

Developmental surveillance
Compare the child with age milestones (for example, sitting without support by 9 months, walking by 18 months, two-word phrases by 2 years) and treat any loss of skills as a red flag.
CDC Learn the Signs. Act Early. milestone checklists
Acute otitis media
Diagnose with moderate or severe tympanic membrane bulging, new otorrhea, or mild bulging with recent ear pain or intense erythema; do not diagnose without middle ear effusion.
CDC Outpatient Clinical Care for Pediatric Populations
Strep testing
Test children with sore throat plus suggestive features; back up a negative rapid test with culture in children and adolescents, and generally do not test children under 3.
CDC Outpatient Clinical Care for Pediatric Populations
Febrile infant UTI
For children 2 to 24 months, confirm UTI with a catheter or suprapubic specimen showing at least 50,000 CFU/mL of a single uropathogen, never bag urine.
CDC Outpatient Clinical Care for Pediatric Populations

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