Chapter 1 of 1511% of exam

Cardiovascular System

Cardiovascular content is the largest single organ-system block on the PANCE blueprint. It spans cardiomyopathy, dysrhythmias, congenital and coronary disease, heart failure, hypertension, shock, inflammatory heart disease, valve disease and vascular disease, tested across history, diagnosis, studies and treatment.

Recognizing the emergency presentations

Several cardiovascular diagnoses are made at the bedside from a short list of findings, and the next step matters more than the name. Instability changes the algorithm: a rhythm that is managed with drugs in a stable patient is shocked in an unstable one. Classic triads and positional clues separate look-alike chest pain syndromes.

Pericarditis vs ischemia
Pericardial pain is pleuritic and eased by sitting up and leaning forward; the ECG shows diffuse ST elevation with PR depression rather than a regional pattern with reciprocal change.
Merck Manual Professional Edition, Pericarditis
Tamponade
Hypotension, distended neck veins and muffled heart sounds with pulsus paradoxus (an inspiratory systolic fall above 10 mm Hg) call for immediate pericardiocentesis.
Merck Manual Professional Edition, Pericarditis
Aortic dissection
Abrupt tearing chest or back pain with pulse deficits suggests dissection; dissection involving the ascending aorta (Stanford type A) is a surgical emergency.
Merck Manual Professional Edition, Aortic Dissection
Unstable tachycardia
A tachycardia with a pulse that causes hypotension or altered mental status is treated with synchronized cardioversion; pulseless VT and VF are treated with defibrillation.
AHA Guidelines for CPR and Emergency Cardiovascular Care

Murmurs and structural disease

The blueprint lists valvular, congenital and cardiomyopathy topics, and exam items usually hinge on where a murmur is heard, what it radiates to, and how it changes with maneuvers. Echocardiography is the standard confirmatory test for structural disease. Congenital lesions often present with a pulse or pressure clue rather than a murmur alone.

Aortic stenosis
A crescendo-decrescendo murmur at the upper sternal border radiating to the carotids, a weak delayed carotid pulse, and the triad of syncope, angina and exertional dyspnea.
Merck Manual Professional Edition, Aortic Stenosis
Hypertrophic cardiomyopathy
The outflow murmur gets louder with maneuvers that lower preload (Valsalva, standing) and softer with handgrip or squatting.
Merck Manual Professional Edition, Hypertrophic Cardiomyopathy
Coarctation of the aorta
Upper-extremity hypertension with weak, delayed femoral pulses and an arm-leg pressure gradient; rib notching appears only in older children.
Merck Manual Professional Edition, Coarctation of the Aorta

Chronic disease management

Hypertension, coronary disease and heart failure account for much of the pharmacotherapy content. Know which drug classes change outcomes and which only relieve symptoms, and which are contraindicated in specific populations such as pregnancy. Distinguish hypertensive urgency from emergency by the presence of acute organ damage.

Four pillars of HFrEF therapy
An ARNI (or ACE inhibitor/ARB), an evidence-based beta-blocker, a mineralocorticoid receptor antagonist and an SGLT2 inhibitor form guideline-directed therapy; loop diuretics treat congestion.
2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure
Digoxin
Digoxin can reduce symptoms and hospitalization in HFrEF but has no proven survival benefit.
Merck Manual Professional Edition, Medications for Heart Failure
Pregnancy and RAAS blockade
ACE inhibitors and ARBs are contraindicated in pregnancy and are replaced with pregnancy-compatible agents.
Merck Manual Professional Edition, Hypertension
Hypertensive emergency
Severe hypertension with acute target-organ damage (encephalopathy, papilledema, heart failure, renal injury) is an emergency; severe elevation without it is urgency.
Merck Manual Professional Edition, Hypertension

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